Pwodwi yo

Gen kenz metalointercalator ki baze sou platinum (II) yo te sentèz ki itilize ligan 1,10-phenanthroline (phen) ranplase, ki gen ladan 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) ak dipirido [3,2-d :2',3'-f]quinoxaline (dpq), ak achiral ethylenediamine (en) ak ligand kiral oksilyè 1S,2S-diaminocyclohexane (S,S-dach) ak 1R,2R-diaminocyclohexane (R,R-dach) .Yo te detèmine sitotoksisite yo nan liy selil L1210 murin lesemi lè l sèvi avèk tès anpèchman kwasans.Konplèks metal ki pi cytotoxik yo se sa yo ki genyen ligand oksilyè S,S-dach ak ligand intercalating 5-CH3-phen.Yon metalointercalator [Pt(5-CH3-phen)(S,S-dach)]Cl2 (5MESS), montre yon ogmantasyon 5-10 fwa nan sitotoksisite konpare ak ajan klinik cisplatin la.Soti nan eksperyans ADN obligatwa pa parèt pa gen okenn diferans enpòtan ant nenpòt nan konplèks metal yo, ki endike ke ni ADN obligatwa afinite ni mòd nan obligatwa / ADN adduct fòme se sèl detèminan nan sitotoksisite nan fanmi sa a ki baze sou platinum(II). metalointercalators.