2-(3,5-Dimethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one Cas:1044871-04-6
Nimewo Katalòg | XD90961 |
Non pwodwi | 2-(3,5-Dimethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one |
CAS | 1044871-04-6 |
Fòmil molekilè | C24H29N3O4 |
Pwa molekilè | 423.5 |
Detay Depo | |
Kòd Tarif Amonize |
Spesifikasyon pwodwi
Aparans | |
Esè | |
Bpwen lwil oliv | 612.6±65.0 °C (Prevwa) |
Dansite | 1.25±0.1 g/cm3 (Prevwa) |
Koyefisyan asidite | (pKa)9.54±0.20(Prevwa) |
RVX-297 se yon trè pisan, oralman aktif BET inhibitor selektif pou BD2.IC50s RVX-297 pou BRD2(BD2), BRD3(BD2), ak BRD4(BD2) te 0.08, 0.05, ak 0.02 μM, respektivman.RVX-297 inibit ekspresyon plizyè jèn selil iminitè enflamatwa.Efikasite RVX-297 nan modèl preklinik nan enflamasyon egi ak otoiminite.
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